SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
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- May 26, 2020
- Download PDF
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- May 26, 2020


- Authors:
- Praveen Anand1,
- Arjun Puranik2,
- Murali Aravamudan2,
- AJ Venkatakrishnan2,
- Venky Soundararajan2
- 1nference Labs, Murugesh Pallya, Bengaluru, Karnataka 560047, India
- 2nference, Inc, One Main Street, East Arcade, Cambridge, MA 02142, USA
- Correspondence: AJ Venkatakrishnan (aj@nference.net), Venky Soundararajan (venky@nference.net)
- Correspondence:
- AJ Venkatakrishnan (aj@nference.net)
- Venky Soundararajan (venky@nference.net)
- Affiliation:
- Timeline:
- Received: May 5, 2020
- Accepted: May 25, 2020
- Published: May 26, 2020 (v1)
- Copyright:
- © 2020, Anand et al.
- This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
- Media coverage:
- Related Tweets:
“We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent in any previous coronavirus sequenced, resulting in the striking mimicry of an identical FURIN-cleavable peptide on the human epithelial sodium channel α-subunit (ENaC-α).”
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elifesciences.org
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC https://doi.org/10.7554/eLife.58603
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC https://doi.org/10.7554/eLife.58603
Viruses
hijack the cellular machinery of humans
to infect their cells and multiply.
The virus causing the global COVID-19 pandemic,
SARS-CoV-2, is no exception.
Identifying which proteins in human cells the virus co-opts
...
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elifesciences.org
1/2
SARS-CoV-2
strategically
mimics proteolytic activation of human ENaC
Abstract
Molecular mimicry
is an evolutionary strategy
adopted by viruses
to exploit the host cellular machinery.
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elifesciences.org
- Affiliation:
- Media coverage:
- Timeline:
- Received: May 5, 2020
- Accepted: May 25, 2020
- Published: May 26, 2020 (v1)
- Copyright:
- © 2020, Anand et al.
- This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
- Related Tweets:
“We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent in any previous coronavirus sequenced, resulting in the striking mimicry of an identical FURIN-cleavable peptide on the human epithelial sodium channel α-subunit (ENaC-α).”
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elifesciences.org
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC https://doi.org/10.7554/eLife.58603
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC https://doi.org/10.7554/eLife.58603
Viruses
hijack the cellular machinery of humans
to infect their cells and multiply.
The virus causing the global COVID-19 pandemic,
SARS-CoV-2, is no exception.
Identifying which proteins in human cells the virus co-opts
...
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elifesciences.org
1/2
SARS-CoV-2
strategically
mimics proteolytic activation of human ENaC
Abstract
Molecular mimicry
is an evolutionary strategy
adopted by viruses
to exploit the host cellular machinery.
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elifesciences.org