Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures
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- May 26, 2020
- Download PDF
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- May 26, 2020





- Aggregate results from 5 selected lab tests for COVIDpos and COVIDneg (matched) patient cohorts over a 60-day period centered around the PCR diagnostic testing date (day 0).
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- Authors:
- Colin Pawlowski1,
- Tyler Wagner1,
- Arjun Puranik1,
- Karthik Murugadoss1,
- Liam Loscalzo1,
- Rajiv K. Pruthi2,
- John C. O’Horo2,
- William G. Morice II2,3,
- John Halamka2,
- Andrew D. Badley2,
- Elliot S. Barnathan4,
- Hideo Makimura4,
- Najat Khan4,
- Venky Soundararajan1
- 1nference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 02142, USA
- 2Mayo Clinic, Rochester MN, USA
- 2Mayo Clinic Laboratories, Rochester MN, USA
- 4Janssen pharmaceutical companies of Johnson & Johnson (J&J), Spring House, PA, USA
- Correspondence: Venky Soundararajan (venky@nference.net)
- Correspondence:
- Venky Soundararajan (venky@nference.net)
- Affiliations:
- Media coverage:
- Copyright:
- The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
- Related Tweets:
Why loss of smell and taste might be the earliest most important symptom with Covid...( The cell science ) #NurseTwitter
https://www.medrxiv.org/content/10.1101/2020.04.19.20067660v4
An interesting preprint suggests that losing your sense of taste or smell is likely the best early indicator of covid infection, even in otherwise asymptomatic patients. So take note if you have those symptoms. https://www.medrxiv.org/content/10.1101/2020.04.19.20067660v4
Screening COVID-19. "Loss of smell (anosmia) with fever a better screen than fever alone. Preprint. COVID-19 patients were 27 times more likely than others to have lost their sense of smell, compared to only 2.6 times more likely to have fever or chills" https://www.medrxiv.org/content/10.1101/2020.04.19.20067660v4
Of #Covid19, the loss of the sense of smell (anosmia) could work particularly well as an add-on to temperature check. https://www.medrxiv.org/content/10.1101/2020.04.19.20067660v4